Flcn autophagy
The tumor suppressor gene FLCN encodes the protein folliculin, also known as Birt–Hogg–Dubé syndrome protein, which functions as an inhibitor of Lactate Dehydrogenase-A and a regulator of the Warburg effect. Folliculin (FLCN) is also associated with Birt–Hogg–Dubé syndrome, which is an … Skatīt vairāk Structure The FLCN gene consists of 14 exons. Location Cytogenetic location: The FLCN gene is located on the short (p) arm of chromosome 17 … Skatīt vairāk Interactions FLCN has been shown to interact through its C-terminus with two new co-chaperones folliculin … Skatīt vairāk • FLCN+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • The BHD Foundation Archived 2024-06-11 at the Wayback Machine supports … Skatīt vairāk • Schmidt LS, Linehan WM (October 2015). "Molecular genetics and clinical features of Birt-Hogg-Dubé syndrome". Nature Reviews. … Skatīt vairāk TīmeklisMutations in FLCN lead to the dysregulation of TFE3, as indicated by the constitutively nuclear localization of TFE3 in a BHD cancer cell line . ... Of the 83 autophagy genes we tested, less than 10% showed more than a twofold increase upon overexpression of TFE3. However, the up-regulated genes encode proteins that function as key …
Flcn autophagy
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Tīmeklis2024. gada 19. febr. · FLCN is a tumor suppressor gene which controls energy homeostasis through regulation of a variety of metabolic pathways including … Tīmeklis2014. gada 22. jūl. · FLCN is a positive driver of autophagy. (A) HK2 control and FLCN knockdown cells were transfected with the ptfMAP1LC3B vector, fixed, and …
Tīmeklis2024. gada 21. nov. · FLCN-FNIP1 is recruited to damaged mitochondria, and this process is inhibited in cells expressing RAB7AS72A. Moreover, nonphosphorylatable … TīmeklisThe FLCN gene provides instructions for making a protein called folliculin. Researchers have not determined the protein's function, but they believe it may act as a tumor …
Tīmeklis2024. gada 18. marts · FLCN is the gene associated with the Birt-Hogg-Dubé neoplastic syndrome in humans, characterized by predisposition to renal cell carcinoma, skin … Tīmeklis2024. gada 1. maijs · Autophagy is an evolutionarily conserved intracellular homoeostatic process wherein cytoplasmic cargo-containing autophagosomes fuse with lysosomes to degrade the cargo 1.
Tīmeklis2014. gada 22. jūl. · Folliculin (FLCN), the protein product of the FLCN gene, is a poorly characterized tumor suppressor protein, currently linked to multiple cellular … self mowing lawn mower reviewsTīmeklis2014. gada 22. jūl. · FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. ... self mulchingTīmeklis2024. gada 14. sept. · The tumor suppressor folliculin (FLCN) is a RagC/D guanosine triphosphatase (GTPase)–activating protein (GAP) that regulates mTORC1 phosphorylation of MiT-TFE transcription factors, controlling lysosome biogenesis and … self mowing lawn mower priceTīmeklis2024. gada 11. sept. · Autophagy is primarily regulated by the transcription factors TFEB and TFE3, which are negatively regulated by mTORC1. Given that FLCN is an … self mulching toiletTīmeklisIn low-amino acid conditions, the lysosomal folliculin complex (LFC) is formed on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, … self mulching clayTīmeklis2024. gada 11. sept. · FLCN’s best described function to date is involved in autophagy regulation. Loss of FLCN Loss of FLCN prevents mTORC1 localization on the lysosome surface and subsequently induces autophagy [62– self mummificationTīmeklis2014. gada 13. nov. · In addition, ULK1 (unc-51-like autophagy activating kinase 1), a homolog of yeast ATG1, is believed to be another downstream effector of mTORC1. ... Concurrently, amino acids promote the GEF activity of Ragulator for GDP-bound RagA/B and the GAP activity of FLCN-FNIP1/2 and LRS for GTP-bound RagC/D, … self mummification yugioh