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Klf4 phase separation

WebFor this ratio, we observe four categories of ligand-modulated phase behaviors of scaffolds: 1) Ligand binding abolishes scaffold phase separation (phase diagrams with red bounding boxes in Fig. 2 C ); 2) ligand binding destabilizes scaffold phase separation (phase diagrams with blue bounding boxes in Fig. 2 C ); 3) ligand binding does not impact … WebKLF4 belongs to the Kruppel-like factor (KLF) family, a group of conserved zinc finger TFs that regulates essential biological processes such as proliferation and development. Reflecting pioneer factor activity, KLF4 uses two out of its three zinc fingers to target a GC-rich hexameric motif enriched within nucleosomal targets22 ( Fig. 7.2 C).

Mechanism of DNA‐Induced Phase Separation for Transcriptional …

WebFeb 25, 2013 · We have identified the zinc-finger transcription factor Kruppel-like factor 4 (Klf4) among the transcription factors that are significantly downregulated in their … WebFeb 14, 2024 · Phase separation of proteins/nucleic acids to form non-membrane organelles is crucial in cellular gene-expression regulation. However, little is known about … calhoun county mi public records https://elyondigital.com

How To Wire 208V Single Phase? (With Diagram Explained)

WebSep 22, 2024 · The study, published in the journal Nature Communications, reveals that the binding of KLF4 can cause DNA to condense into a separate liquid phase in a process … WebAug 28, 2013 · KLF4, as a member of KLF family, expresses in a wide range of tissues in mammals, and plays a critical role in regulating a diverse array of cellular processes … WebKLF4 is thought to induce long-range pluripotency contacts through condensation at promoters of pluripotency factors (Sharma et al. 2024 ). However, KLF4 condensation … coachman lusso 11 2022

Structural Design and Performance Analysis of Three-Phase …

Category:Role of Klf4 in the Regulation of Apoptosis and Cell Cycle in Rat ...

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Klf4 phase separation

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WebDec 21, 2024 · Phase separation Germ granules are the earliest known and most studied phase-separated membrane-less organelles in germ cells during early embryonic … WebApr 12, 2024 · Hydrocyclones are widely used in the separation of two-phase immiscible mixtures. In various application scenarios, three-phase hydrocyclones (3PH) are often urgently needed. In this work, the typical 3PHs are classified into six categories according to their structural characteristics. A comprehensive analysis of their structural feature ...

Klf4 phase separation

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WebApr 11, 2024 · Phase separation of biomolecules occur to form membraneless compartments in response to extra- or intra-cellular stimuli. Recently, phase separation has been identified in different immune signaling pathways, of which cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling is an important innate immune … WebSep 5, 2006 · We show that overexpression of KLF4 induces arrest and apoptosis in the G 1 phase of the cell cycle. KLF4-mediated death, but not cell-cycle arrest, can be rescued by Bcl-X L overexpression. Transformed pro/pre-B cells expressing KLF4 display increased expression of p21 CIP and decreased expression of c-Myc and cyclin D2. Tetracycline …

WebFeb 3, 2024 · We show that Klf4 can phase separate on its own at high concentrations, but at low concentrations, Klf4 only forms condensates on DNA. Using optical tweezers, we … WebApr 4, 2024 · KLF4 is a therapeutically tractable brake on fibroblast activation that promotes resolution of pulmonary fibrosis. Epithelial-mesenchymal reprogramming by KLF4-regulated Rictor expression contributes to metastasis of non-small cell lung cancer cells.

WebMar 23, 2024 · The evident changes observed in cell morphology together with the downregulation of the naïve pluripotency markers Nanog, Klf4 and Esrrb and the increase of the mRNA levels of primed... WebHere we investigate the role of DNA in nucleation of condensates, using the pioneer transcription factor KLF-4. We show that KLF-4 forms liquid-like condensates on the DNA surface at physiological concentrations, below the one required for Klf4 phase separation.

WebApr 14, 2024 · 63.Multivalent interactions between molecular components involved in fast endophilin mediated endocytosis drive protein phase separation. 参与快速内啡肽介导的内吞作用的分子成分之间的多价相互作用驱动蛋白质相分离。 64.Liquid-infused microstructured bioadhesives halt non-compressible hemorrhage.

WebAug 26, 2024 · Admittedly, phase separation is a young biological research direction, and many problems persist to overcome how to precisely regulate phase separation, such as … coachman lusso 2 for saleWebDec 26, 2024 · 2.1. LH Regulates the Expression of Klf4, Bcl-2, and Cell Cycle Genes in Preovulatory GCs. To investigate changes in the expression of Klf4 and the genes regulating apoptosis and the cell cycle in preovulatory GCs in the early phase of LH exposure, cells were cultured in the presence of LH (0, 100, 200 ng/mL) for 45 min, and real-time PCR … calhoun county mississippi extension officeWebApr 17, 2024 · The relationship between the molecular weight of PVDF and its distribution, phase separation, crystallization behavior and spinning process has been systematically studied. The effects of three factors on the microstructure and properties of the PVDF membrane have been analyzed. The flow behaviors of the PVDF/diluent and PVDF melt … calhoun county mi road department projectsWebTo evaluate the role of KLF4 in cell-cycle progression, we silenced KLF4 by siRNAs in MCF-7 cells. FACS analysis showed a significant increase in the proportion of cells at S phase (Fig. 5E). Moreover, cell-proliferation analysis showed that silencing KLF4 promotes MCF-7 cell growth (Fig. 5F). Together the results indicate that KLF4 has an ... calhoun county mi recorderWebApr 3, 2024 · Gliomas, accounting for ~25% of primary CNS tumors, have an average mortality rate of 4.43 per 100,000 and 16,606 deaths per year [1, 2].Standard therapies of surgery resection combined with ... calhoun county missing personWebOct 19, 2016 · The newt RPE has also been studied with respect to the molecular mechanism of cell entry into the S-phase after RPE separation from the NR [62,63]. The authors of the first study analyzed an activity of MEK-ERK signaling in RPE just after NR removal from the newt eye and found it activated within 30 min after retinectomy. ... Mitf, … calhoun county mississippi mapWebAug 28, 2013 · These studies suggest that KLF4 is a critical factor in regulating entry of the cells into the mitotic phase. Finally, KLF4 was found both necessary and sufficient in preventing centrosome amplification ... Characterization of different KLF4 isoforms and/or separation of distinct KLF4 expressing cells will be necessary for dissecting specific ... calhoun county mi treasurer