Organic anion transporter family
WitrynaSolute carrier family. The solute carrier ( SLC) group of membrane transport proteins include over 400 members organized into 66 families. [1] [2] Most members of the SLC group are located in the cell membrane. The SLC gene nomenclature system was originally proposed by the HUGO Gene Nomenclature Committee ( HGNC) and is the … WitrynaThe organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22 (solute carrier 22) transporter family, has received a great deal of attention because of its role in handling of common drugs (antibiotics, antivirals, diuretics, nonsteroidal anti-inflammatory drugs), toxins (mercury, aristolochic acid), and …
Organic anion transporter family
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Witryna9 mar 2024 · OATP; Organic Anion Transporter Polypeptide (OATP) family; NM_001145212.3 → NP_001138684.1 solute carrier organic anion transporter family member 2B1 isoform 3. Status: REVIEWED. Description Transcript Variant: This variant (3) is missing 3 consecutive coding exons from the 5' end compared to transcript … WitrynaRecently, the molecular identity of the organic anion transport system, the OAT family, was revealed. To date, six OAT members have been identified and shown to have important roles not only in detoxification in the kidneys, liver and brain, but also in the reabsorption of essential compounds such as urate.
Members of the Organo Anion Transporter (OAT) Family (organic-anion-transporting polypeptides, OATP) are membrane transport proteins or 'transporters' that mediate the transport of mainly organic anions across the cell membrane. Therefore, OATPs are present in the lipid bilayer of the cell membrane, … Zobacz więcej Proteins of the OAT family catalyze the Na -independent facilitated transport of fairly large amphipathic organic anions (and less frequently neutral or cationic drugs), such as bromosulfobromophthalein, prostaglandins, … Zobacz więcej The OATPs play a role in the transport of some classes of drugs across the cell membrane, particularly in the liver and kidney. In the liver, OATPs are expressed on the basolateral membrane of hepatocytes, transporting compounds into the hepatocyte for Zobacz więcej The various paralogues in a mammal have differing but overlapping substrate specificities and tissue distributions as summarized by Hagenbuch and Meier. These authors also provide a phylogenetic tree of the mammalian members of the family, … Zobacz więcej The table below shows the 11 known human OATPs. Note: Human OATPs are designated with capital letters, animal Oatps are … Zobacz więcej OATPs are present in many animals, including fruit flies, zebrafish, dogs, cows, rats, mice, monkeys and horses. OATPs are not present … Zobacz więcej Witryna11 sty 2012 · By searching an EST database for organic anion transporter (OATP, or SLC21A3; 602883)- and prostaglandin transporter (SLC21A2; 601460)-related sequences, Abe et al. (1999) identified ESTs encoding SLC21A6, which they called LST1. The SLC21A6 gene encodes a deduced 691-amino acid protein containing 12 …
WitrynaView/Edit Mouse. Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene. [5] [6] This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal … Witryna10 sty 2003 · Mediates the Na +-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, taurocholate, estrone 3-sulfate, estradiol-17beta-glucuronide and prostaglandin E2 (PGE2) (PubMed:10873595, PubMed:19129463). Shows a pH-sensitive substrate specificity …
The organic anion transporter 1 (OAT1) also known as solute carrier family 22 member 6 (SLC22A6) is a protein that in humans is encoded by the SLC22A6 gene. It is a member of the organic anion transporter (OAT) family of proteins. OAT1 is a transmembrane protein that is expressed in the brain, the placenta, the eyes, smooth muscles, and the basolateral membrane of proximal tubular cel…
Witryna18 maj 2010 · Solute carrier organic anion transporter family member 5A1. Alternative names. Organic anion transporter polypeptide-related protein 4 (OATP-RP4; OATPRP4) Solute carrier family 21 member 15; Gene names. Name. SLCO5A1. Synonyms. OATP5A1, SLC21A15. Organism names. Organism. Homo sapiens (Human) bonnie littlejohnWitryna10 sty 2003 · Solute carrier organic anion transporter family member 1A5. Alternative names. Organic anion-transporting polypeptide 3 (OATP-3) Sodium-independent organic anion transporter 3; Solute carrier family 21 member 7; Gene names. Name. Slco1a5. Synonyms. Oatp1a5, Oatp3, Slc21a7, Slco1a2. Organism names. Organism. bonnie johnson utkWitrynaNa + -independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), at the plasmam membrane ( PubMed: 7557095, PubMed: 19129463 ). Responsible for intestinal … bonneton jean pierreWitryna1 sty 2015 · The organic anion transporter (OAT) subfamily, which constitutes roughly half of the SLC22 (solute carrier 22) transporter family, has received a great deal of attention because of its role in handling of common drugs (antibiotics, antivirals, diuretics, nonsteroidal anti-inflammatory drugs), toxins (mercury, aristolochic acid), and … hukum hak kekayaan intelektual hkiWitrynaSolute carrier organic anion transporter family member 1B1. Short names. SLCO1B1. Alternative names. Liver-specific organic anion transporter 1 (LST-1 1 publication) OATP-C 1 publication. Organic anion transporter SLC21A6 1 publication. Sodium-independent organic anion-transporting polypeptide 2 (OATP-2 2 publications) hukum haji dan umrah tingkatan 4Witryna1 maj 2024 · Introduction. The solute carrier superfamily encompasses many transporters that play important roles in the uptake and distribution of both endogenous compounds and xenobiotics (Hagenbuch and Stieger, 2013).Among these are the organic anion transporting polypeptides (OATPs), classified in the SLCO family, … hukum hak kekayaan intelektual pdfWitryna1 sty 2006 · Several families of multispecific organic anion and cation transporters, including OAT family transporters, have recently been identified by molecular cloning. The OAT family consists of six isoforms (OAT1 – 4, URAT1, and rodent Oat5) and they are all expressed in the kidney, while some are also expressed in the liver, brain, and … hukum hadits syadz