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Sox4 chip

Web2. aug 2024 · SOX4 gene expression correlates with advanced cancer stages and poor survival rate in bladder cancer, supporting a potential role as a regulator of the bladder CSC properties. SOX4 might serve as a biomarker of the aggressive phenotype, also underlying progression from NMIBC to MIBC. The amplicon in chromosome 6 contains SOX4 and … Web17. jún 2024 · SOX4 served as an oncogene and reversed the effects of METTL14 in CRC. a. The SOX4 knockdown efficiency was proved at the protein levels in HCT116 and HCT8 …

The transcription factor Sox4 is a downstream target of …

Web9. mar 2024 · The target sequence of the transcription factor Sox9 in IESCs was investigated via chromatin immunoprecipitation (ChIP) combined with deep sequencing (ChIP-seq). Increased Sox9 expression is accompanied by the loss of methylation in its promoter in IESCs. ... Sox4, and Fzd8, but also functions as a potential transcriptional inhibitor at a ... Web3. máj 2011 · Tbx3, SOX4, and SOX2 ChIP data, identify a region in intron 1 of Gja1 bound by all tree proteins and subsequent ChIP experiments verify that this sequence is bound, in vivo, in the developing heart. In a luciferase reporter assay, this element displays a synergistic antagonistic response to co-transfection of Tbx3 and Sox4 and in vivo, in ... interactif ratp https://elyondigital.com

Biomedicines Free Full-Text Stem-Like Signature Predicting …

Web21. jan 2024 · The GATA2 ChIP-seq peaks generated from resting BMMCs (Fig. 2) and MITF ChIP-seq data used in Figs. 2 and 7 were downloaded from the GEO database “GSE48086” … Web(A, B) Changes in the profiles of SOX4 and RELA ChIP-seq peaks in the Sox4 and Sox11 genomic locus upon TNF treatment. (C) Fold-change Sox4 and Sox11 luciferase reporter activity in HEK293 cells transfected with SOX4 expression plasmids and treated with 10ng/mL TNF for 16h. *p-value < 0.05 by student’s t-test compared to untreated condition. Web15. jan 2009 · SOX4 is up-regulated by TGFβ-1 treatment , and we found SMAD4 sites are significantly enriched in the SOX4 ChIP-chip peaks , suggesting that SOX4 affects key … interactif roissy

SOX4 promotes beige adipocyte-mediated adaptive …

Category:METTL14-mediated N6-methyladenosine modification of SOX4 …

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Sox4 chip

Mouse Anti-SOX4 Monoclonal Antibody (154C4a), Unconjugated

WebChIP.Two 90% confluentP150sof bothLNCaP-YFPand LNCaP-YFP/HA-SOX4 or RWPE-1-YFP and RWPE-1-YFP/HA-SOX4 cells were formaldehyde fixed and sonicated, and ChIPassay was performed, as described previously (23). Anti-HA 12CA5 or mouse IgG was used to immunoprecipitate protein-DNA complexes overnight at 4jC and collected using Dynal … Web25. feb 2016 · 健康所博士研究生周宸琳等人和同济大学博士后杨晓勤在健康所研究员金颖和同济大学教授张勇的带领和指导下开展合作研究，通过 ChIP-seq、 RNA-seq 和蛋白质谱等手段，全面比较分析了 SOX2 在 hESCs 和 hNPCs 中的转录调控网络和蛋白质相互作用网络。

Sox4 chip

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Web13. máj 2024 · The role of SOX4 in angiogenesis and tumor microenvironment modulation was recently documented in breast cancer but remains unclear in hepatocellular … http://thebrain.bwh.harvard.edu/pubs/Scharer-SOX4.pdf

Web9. apr 2024 · ChIP–western blot analysis demonstrating equivalent levels of SMARCA4 protein pulldown in cells treated with either siRNA targeting SOX4 or control siRNA in … Web14. apr 2024 · Gastric cancer. LINC00511 has been shown to promote progression of gstaric acnecr through regulating SOX4 expression and epigenetically suppressing PTEN to induce activity of PI3K/AKT pathway (Wang et al., 2024).Moreover, LINC00511 can promote growth of gastric tumors through acting as a molecular sponge for miR-124-3p and regulating …

WebIn order to explore the expression of Sox4 in WT tumor, we searched relevant chips through GEO database and found that Sox4 was highly expressed in WT tumor tissue in GSE66405 (See Figure 6C). For further determining the expression of Sox4 in WT children, ... WebHere, we focused on six sex determining region Y-related HMG-box (SOX) transcription factors (SOX4, 6, 8, 9, 10, and 11) highly expressed in TNBCs. Our siRNA screening assay …

WebAs shown in Fig. 5a, our Chip-seq data shows that the same region of Gja1 in intron 1 as found in the SOX2 and SOX4 ChIP experiments is also bound by Tbx3, implicating that it may be a conserved ...

WebSOX4 is a transcription factor with pleiotropic functions required for different developmental processes, such as corticogenesis. As with all SOX proteins, it contains a conserved high mobility group (HMG) and exerts its function via interaction with other transcription factors, such as POU3F2. Recently, pathogenic SOX4 variants have been identified in several … john edwards medium knoxville tnWebInterestingly, ChIP-seq assays revealed that 70.4% of SOX4 peak summits were within 50bp of the RELA peak summits suggesting that both proteins bind in close-proximity on regulatory sequences ... john edwards medium tourWebATAC-seq, ChIP-qPCR, and dual-luciferase reporter assays were carried out to verify the role of SOX4/EZH2 in the modulation of METTL3 expression upon TMZ treatment. We demonstrated that TMZ treatment upregulated the expression of the m6 A methyltransferase METTL3, thereby increasing m6 A modification of histone modification … interacting binariesWeb5. júl 2012 · Sox4 overexpression enhances survival and cell-cycle progression of mouse bone marrow cells in vitro. (A) Flow cytometry analysis of retrovirally transduced and … interactif secondaireWeb1. jan 2024 · Chromatin immunoprecipitation (ChIP) experiments in human BT549 TNBC cells with a SOX4 versus control IgG antibody identified SOX4 specific peaks in the regulatory regions of interferon pathway genes (such as IRF7 and ISG15) and MHC-I pathway genes (including TAP1, TAP2, PSMB9, HLA-B and HLA-C) (Fig. 6F, Table S2). … john edwards jaguar serviceWeb3. feb 2016 · Sox4 was also able to promote β-catenin-mediated transcription of the Slug gene through formation of transcriptional complexes with β-catenin and p300, independent of TCF4 status. ... e ChIP assay data showing that Sox4 is bound to Slug promoter regions, in particular after culturing in STK2 for 3 days. interactifs ukWeb2. mar 2024 · The SOX4 ChIP-seq dataset was used to determine all SOX4-targeted tRNAs based on peak score. The tRNA database (GtRNAdb; http://gtrnadb.ucsc.edu/) was used … interactifs formation