Stc1 mitochondria
WebJun 9, 2024 · Of note, mitochondrial Stc1 associates with mitochondrial megalin of various MW, from an approximate 600 kD to an approximate 100 kD, and while bands of similar size/migration are observed in all cells, … Webd STC1 interacts with CRT and traps CRT in mitochondria d STC1 impairs APC phagocytosis and T cell activation via trapping CRT d STC1 functions as an ‘‘eat-me’’ signal blocker and may be a phagocytosis checkpoint ... STC1 is reported as a hormone-like protein and may mediate multiple biological activities (Yeung et al., 2012). None-
Stc1 mitochondria
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WebJul 4, 2024 · STC1 upregulates uncoupling protein 2 expression level and decreases mitochondrial membrane potential. Thus, it increases lactate production for anaerobic … WebThe mammalian homolog of the fish calcium regulatory hormone stanniocalcin-1 (STC1) is ubiquitously expressed and likely functions in an autocrine/paracrine fashion. Mammalian …
WebMay 19, 2024 · A mitochondrial membrane potential analysis showed that the red-green fluorescence ratio in the CON and SCON groups was 3.15 ± 0.13% and 2.57 ± 0.1%, … WebConfocal deconvolution immunofluorescence studies reveal co-localization of Mito-red (mitochondrial marker) with native Lrp2 (a), Stc1 (b) and Sirt3 (c) in C2C12 cells (similar results are...
WebFeb 1, 2010 · As to targeting of STC1 to the mitochondria, two models have been proposed by Sazonova et al. : one model envisions the membrane receptor acting first as a signal … Mammalian stanniocalcins are secreted phosphoglycoproteins1, and published work from our lab shows extracellularly applied STC1 is targeted to the mitochondria in WT C2C12 cells12; but fails to reach the mitochondria in Lrp2 KO C2C12 cells12. ExPASy-PROSITE analysis of STC1 protein predicts no mitochondrial … See more The open reading frame for human megalin mRNA encodes 4612 aa16. The primary structure of megalin predicts a type I transmembrane protein containing … See more The extracellular region of megalin contains 3 types of cysteine-rich repeat motifs: 36 ligand-binding motifs (class A), 1 EGF motif (class B.1), and 15 growth factor … See more To determine STC1 domains that interact with megalin, we co-expressed in HEK293T cells, full-length hLRP2/megalin (C-terminus FLAG-tagged) with full-length … See more
WebAssociation between native megalin/Lrp2, Stc1 and Sirt3 in whole cell (c) and mitochondrial (d) lysates of kidney, C2C12, Raw264.7 and HEK293T cells. Immunoprecipitation was carried out using...
WebSep 22, 2015 · Introduction. The mammalian pro-survival protein STC1 is expressed in many tissues and organs including the kidneys [].It is released to the extracellular milieu [], and binds to a cell-surface protein [], followed by internalization and targeting to the inner mitochondrial membrane [4,5].It is defined as a paracrine/intracrine protein; i.e., … induction vs gas cooktop 2018WebFeb 1, 2010 · A report by James and coworkers suggested uncoupling of the mitochondria by STC1. In agreement with this observation, our data suggest that STC1 upregulates the expression of mitochondrial uncoupling protein-2 (UCP2) in macrophages and UCP3 in cardiomyocytes . And it is highly likely that STC1 upregulates uncoupling proteins in other … logarithms bbcThis gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The only known molecular function of human Stanniocalcin-1 to date is a SUMO E3 ubiquitin ligase activity in the SUMOylation cycle. However, STC1 interacts with many proteins in the cytoplasm, mitochondria, endoplasmatic reticulum, and in dot-like fashion in the cell nucleus. The N-terminal region of STC1 is the function … logarithms chapterWebJan 1, 2024 · STC1 is a mitochondrial intracrine molecule (defined as an extracellular signaling molecule that enters cells, translocates to mitochondria and alters their function). STC1 activates AMPK, which in turn upregulates uncoupling proteins (UCPs) and SIRT3, promoting mitochondrial anti-oxidant defenses. induction vs gas cooktop temp controlWebApr 6, 2009 · Stanniocalcin-1 (STC1) is a glycoprotein that has been highly conserved from fish to mammals (Chang et al., 2003).In fish, it functions as a classic hormone that is secreted from endocrine glands ... induction vs gas cooking temperaturesWebFeb 20, 2024 · We discovered (1) increased expression of APOL1 in HR and nine other significant differentially expressed genes, including stanniocalcin (STC1), which has a role in mitochondrial and calcium-related processes, (2) differential correlations between HR and LR APOL1 and metabolism pathway genes, but similar correlations with extracellular … logarithms change of base ruleWebApr 7, 2024 · Stanniocalcin 1 (STC1) plays an integral role in ovarian cancer (OC). However, the functional role of STC1 in metastasis, lipid metabolism and cisplatin (DDP) chemoresistance in OC is not fully understood. Methods Single-cell sequencing and IHC analysis were performed to reveal STC1 expression profiles in patient tissues. logarithms as level maths